A single-component research material supplied for controlled research environments. FOXO4 (10 mg) is a synthetic peptide fragment used in research exploring cellular senescence, apoptosis regulation, and FOXO transcription factor signaling pathways in controlled model systems.
• FOXO4
• Appearance: Lyophilized powder in a sealed research vial
$300.00
These compounds are intended for in-vitro research use only and are not approved for human or veterinary use, consumption, or therapeutic application.
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Research Focus
Research Focus
- Investigation of FOXO4-p53 interaction in cellular senescence models
- Studies of apoptosis induction pathways in aging research
- Peptide identity and purity verification via HPLC/LC-MS
- Stability and solubility profiling under various laboratory storage conditions
Supportive Studies
-
Landmark senolytic study – targeted apoptosis of senescent cells
Baar MP, et al. Cell (2017)
Demonstrates that FOXO4-DRI disrupts FOXO4–p53 binding, selectively inducing apoptosis in senescent cells and improving tissue homeostasis, kidney function, hair density, and physical activity in aged mice.
https://www.sciencedirect.com/science/article/pii/S0092867417303993
https://pubmed.ncbi.nlm.nih.gov/28646959/ -
Mechanistic basis – FOXO4 as a survival factor in senescent cells
Baar MP, et al. Cell (2017, mechanistic analyses)
Establishes FOXO4 as a key protector of senescent cells via p53-dependent mechanisms, providing the mechanistic foundation for FOXO4-DRI as a senolytic strategy.
https://pubmed.ncbi.nlm.nih.gov/28646959/ -
FOXO transcription factors & longevity biology (contextual cornerstone)
Eijkelenboom A, Burgering BMT. Nature Reviews Molecular Cell Biology (2013)
Reviews FOXO proteins as central regulators of cellular stress resistance, DNA repair, apoptosis, and longevity signaling, supporting FOXO4 as a rational aging target.
https://www.nature.com/articles/nrm3600
https://pubmed.ncbi.nlm.nih.gov/23880507/ -
FOXO4 expression in senescence maintenance
Kim HK, et al. Journal of Biological Chemistry (2015)
Shows FOXO4 upregulation in senescent cells and its role in regulating senescence-associated genes and stress resistance.
https://www.jbc.org/article/S0021-9258(20)41257-5/fulltext
https://pubmed.ncbi.nlm.nih.gov/25838542/ -
Senescent cell clearance improves healthspan (senolytic paradigm)
Baker DJ, et al. Nature (2016)
Demonstrates that removal of senescent (p16Ink4a-positive) cells extends healthspan, providing broader validation for senolytic approaches such as FOXO4-DRI.
https://www.nature.com/articles/nature16932
https://pubmed.ncbi.nlm.nih.gov/26840489/
Storage Instructions
All research peptides offered are manufactured using a lyophilization (freeze-drying) process,
which is designed to enhance stability during storage and transport. When stored appropriately,
lyophilized materials are generally stable at room temperature for extended periods prior to reconstitution.
Lyophilized (Unreconstituted) Material
- Store vials away from heat, moisture, and direct light.
- For short-term storage, refrigeration at approximately 4°C (39°F) is suitable.
- For long-term storage (months to years), vials may be stored in a freezer at approximately −80°C (−112°F).
- Freezing is the preferred method for preserving stability over extended storage durations.
Reconstituted Material
- Once reconstituted using appropriate laboratory-grade solvents, materials should be stored refrigerated.
- Under refrigerated conditions, reconstituted material is commonly considered stable for up to 30 days,
depending on solvent choice, concentration, handling, and experimental conditions. - Avoid repeated freeze–thaw cycles, as these may impact material integrity.
About Lyophilization
Lyophilization is a dehydration process in which compounds are frozen and exposed to reduced pressure,
allowing ice to sublimate directly from solid to vapor. This process results in a dry, crystalline structure
that enhances stability prior to reconstitution.
⚠️ Important Notice: These materials are intended for research and laboratory use only.
Not for human or veterinary use, consumption, or application.
Recent Certificate of Analysis (COA)
99%+ Purity
Third-Party Lab Tested
Satisfaction Guaranteed
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Frequently Asked Questions
Essential information about our research-grade peptides and quality standards.
What are research peptides?
Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.
Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.
What does peptide purity mean and why does it matter?
Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).
Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.
How do you ensure peptide quality?
We maintain rigorous quality control through a multi-step verification process:
- HPLC Analysis: Every batch tested to verify ≥99% purity
- Mass Spectrometry: Molecular weight confirmation for peptide identity
- Third-Party Testing: Independent laboratory verification
- Sterility Protocols: Aseptic handling and packaging procedures
- Batch Documentation: Complete traceability from synthesis to delivery
What does "Research Use Only" mean?
“Research Use Only” (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.
How are peptides shipped?
All orders are shipped with research-grade handling protocols:
- Packaging: Insulated containers with cold packs when required
- Carriers: USPS Priority Mail
- Processing: Orders placed before 12 PM EST ship same business day
- Tracking: Full tracking information provided via email
What is your return and refund policy?
We stand behind every product:
- Quality guarantee: Full replacement or refund if products don’t meet stated specifications
- Shipping issues: Free replacement for damaged or lost shipments
- Unopened returns: Accepted within 30 days for store credit
