A single-component research material supplied for controlled research environments. Pinealon (20 mg) is a synthetic short peptide sequence studied for its potential role in neuroendocrine regulation, cognitive function research, and epigenetic pathway exploration in model systems.
• Pinealon
• Appearance: Lyophilized powder in a sealed research vial
$110.00
These compounds are intended for in-vitro research use only and are not approved for human or veterinary use, consumption, or therapeutic application.
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Research Focus
Research Focus
- Peptide identity and purity assessment via HPLC/LC-MS
- Studies on neuropeptide signaling and gene expression in neuronal cell culture models
- Exploration of Pinealon’s effect on oxidative stress response in laboratory assays
- Stability and solubility profiling of Pinealon under laboratory storage conditions
Supportive Studies
Pinealon is a short synthetic tripeptide (Glu-Asp-Arg) derived from the pineal peptide complex studied primarily in neuroprotection, cognitive aging, stress resilience, and hypoxia-related brain injury. Most of the evidence originates from Russian/Eastern European research programs and includes cellular, animal, and limited human observational/clinical data. Mechanistically, Pinealon is described as a neuroregulatory and epigenetic peptide, influencing gene expression related to neuronal survival, oxidative stress response, and mitochondrial function. Across models, Pinealon has demonstrated cognitive-supportive, anti-hypoxic, antioxidant, and stress-protective effects, particularly relevant to aging brain physiology rather than acute disease treatment.
Key Evidence & Links
-
Foundational neuroprotective and geroprotective review
Khavinson VKh, et al. Neuroendocrinology Letters (2003)
Reviews pineal peptides (including Pinealon) and their role in brain aging, cognitive decline, and stress adaptation.
https://pubmed.ncbi.nlm.nih.gov/14523360/ -
Anti-hypoxic and antioxidant effects in brain tissue (preclinical)
Khavinson VKh, et al. Bulletin of Experimental Biology and Medicine (2002)
Demonstrated Pinealon’s ability to improve neuronal resistance to hypoxia and oxidative stress in experimental models.
https://pubmed.ncbi.nlm.nih.gov/12444451/ -
Cognitive function and memory support (animal models)
Myasoedov NF, et al. Neuroscience and Behavioral Physiology (2001)
Showed improvements in learning and memory performance in aging and stress-exposed animals receiving Pinealon.
https://pubmed.ncbi.nlm.nih.gov/11485764/ -
Gene expression modulation in neuronal cells (epigenetic signaling)
Khavinson VKh, et al. Bulletin of Experimental Biology and Medicine (2005)
Demonstrated that Pinealon influences gene expression associated with neuronal survival and stress resistance, supporting its classification as a bioregulatory peptide.
https://pubmed.ncbi.nlm.nih.gov/16052147/ -
Clinical observations in elderly populations (cognition & stress tolerance)
Khavinson VKh, et al. Advances in Gerontology (2004)
Reported improvements in cognitive performance, attention, and psycho-emotional stability in older adults receiving pineal peptides.
https://pubmed.ncbi.nlm.nih.gov/15609873/ -
Book reference — peptides, brain aging, and neuroregulation
Khavinson VKh. Peptides and Aging. Springer (2010)
Comprehensive reference summarizing Pinealon and related peptides in neuroaging, cognition, and stress physiology.
https://link.springer.com/book/10.1007/978-3-642-27814-3
Storage Instructions
All research peptides offered are manufactured using a lyophilization (freeze-drying) process,
which is designed to enhance stability during storage and transport. When stored appropriately,
lyophilized materials are generally stable at room temperature for extended periods prior to reconstitution.
Lyophilized (Unreconstituted) Material
- Store vials away from heat, moisture, and direct light.
- For short-term storage, refrigeration at approximately 4°C (39°F) is suitable.
- For long-term storage (months to years), vials may be stored in a freezer at approximately −80°C (−112°F).
- Freezing is the preferred method for preserving stability over extended storage durations.
Reconstituted Material
- Once reconstituted using appropriate laboratory-grade solvents, materials should be stored refrigerated.
- Under refrigerated conditions, reconstituted material is commonly considered stable for up to 30 days,
depending on solvent choice, concentration, handling, and experimental conditions. - Avoid repeated freeze–thaw cycles, as these may impact material integrity.
About Lyophilization
Lyophilization is a dehydration process in which compounds are frozen and exposed to reduced pressure,
allowing ice to sublimate directly from solid to vapor. This process results in a dry, crystalline structure
that enhances stability prior to reconstitution.
⚠️ Important Notice: These materials are intended for research and laboratory use only.
Not for human or veterinary use, consumption, or application.
Recent Certificate of Analysis (COA)
99%+ Purity
Third-Party Lab Tested
Satisfaction Guaranteed
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Frequently Asked Questions
Essential information about our research-grade peptides and quality standards.
What are research peptides?
Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.
Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.
What does peptide purity mean and why does it matter?
Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).
Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.
How do you ensure peptide quality?
We maintain rigorous quality control through a multi-step verification process:
- HPLC Analysis: Every batch tested to verify ≥99% purity
- Mass Spectrometry: Molecular weight confirmation for peptide identity
- Third-Party Testing: Independent laboratory verification
- Sterility Protocols: Aseptic handling and packaging procedures
- Batch Documentation: Complete traceability from synthesis to delivery
What does "Research Use Only" mean?
“Research Use Only” (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.
How are peptides shipped?
All orders are shipped with research-grade handling protocols:
- Packaging: Insulated containers with cold packs when required
- Carriers: USPS Priority Mail
- Processing: Orders placed before 12 PM EST ship same business day
- Tracking: Full tracking information provided via email
What is your return and refund policy?
We stand behind every product:
- Quality guarantee: Full replacement or refund if products don’t meet stated specifications
- Shipping issues: Free replacement for damaged or lost shipments
- Unopened returns: Accepted within 30 days for store credit








