A single-component research material supplied for controlled research environments. VIP10 (Vasoactive Intestinal Peptide, 10 mg) is a synthetic neuropeptide used in research focused on smooth muscle relaxation, circadian rhythm regulation, and immune signaling pathways in controlled model systems.
• VIP10 (Vasoactive Intestinal Peptide)
• Appearance: Lyophilized powder in a sealed research vial
$170.00
These compounds are intended for in-vitro research use only and are not approved for human or veterinary use, consumption, or therapeutic application.
You may also like...
You may also like…
-
Glutathione
Price range: $100.00 through $150.00 This product has multiple variants. The options may be chosen on the product page -
NAD+
Price range: $160.00 through $280.00 This product has multiple variants. The options may be chosen on the product page -
BPC-157
Price range: $70.00 through $180.00 This product has multiple variants. The options may be chosen on the product page
Research Focus
Research Focus
- Characterization of VIP’s effects on vasodilation and smooth muscle cell models
- Studies on immune modulation and cytokine signaling pathways
- Research exploring VIP’s role in circadian rhythm regulation and gastrointestinal physiology
- Stability and solubility profiling under laboratory storage conditions
Supportive Studies
Vasoactive Intestinal Peptide (VIP) is a 28–amino-acid neuropeptide with broad immunomodulatory, anti-inflammatory, vasodilatory, and barrier-protective effects. It functions as a key neuro-immune regulator, signaling through VPAC1 and VPAC2 receptors expressed on immune cells, epithelial tissues, and the nervous system. Across human, animal, and mechanistic studies, VIP has been shown to downregulate pro-inflammatory cytokines, promote immune tolerance, support gut and pulmonary epithelial integrity, modulate Th1/Th2/Th17 balance, and protect tissues during inflammatory and autoimmune stress. Because of these properties, VIP has been extensively studied in autoimmunity, inflammatory bowel disease, pulmonary disease, sepsis, and neuroinflammation, with both experimental and early clinical human data supporting its biological relevance.
Key Evidence & Links
-
Foundational immunomodulatory review (mechanism + disease relevance)
Delgado M, Ganea D. Physiological Reviews (2013)
Comprehensive review detailing VIP’s role in immune tolerance, cytokine regulation, and inflammation resolution across autoimmune and inflammatory diseases.
https://journals.physiology.org/doi/full/10.1152/physrev.00024.2012
https://pubmed.ncbi.nlm.nih.gov/23589895/ -
Innate & adaptive immune regulation (cytokines, T cells, macrophages)
Delgado M, et al. Nature Reviews Immunology (2004)
Seminal paper describing VIP as a Th2-skewing, anti-inflammatory neuropeptide that suppresses TNF-α, IL-6, IL-12, and IFN-γ.
https://www.nature.com/articles/nri1314
https://pubmed.ncbi.nlm.nih.gov/15040585/ -
Gut barrier & inflammatory bowel disease context
Abad C, et al. Gastroenterology (2003)
Demonstrates that VIP protects against experimental colitis, preserves epithelial integrity, and reduces inflammatory signaling in gut mucosa.
https://pubmed.ncbi.nlm.nih.gov/12671886/ -
Pulmonary inflammation & epithelial protection
Voice JK, et al. American Journal of Physiology – Lung Cellular and Molecular Physiology (2001)
Shows VIP reduces airway inflammation, improves epithelial function, and modulates immune responses in pulmonary disease models.
https://pubmed.ncbi.nlm.nih.gov/11350825/ -
Sepsis & systemic inflammation models
Delgado M, et al. Journal of Immunology (1999)
VIP administration reduced mortality, cytokine storm, and tissue injury in endotoxemia/sepsis models.
https://pubmed.ncbi.nlm.nih.gov/10452963/ -
Neuroprotection & neuroinflammation
Gonzalez-Rey E, et al. Trends in Molecular Medicine (2007)
Reviews VIP’s role in neuroprotection, microglial regulation, and CNS immune balance.
https://pubmed.ncbi.nlm.nih.gov/17367965/ -
Human clinical relevance (pulmonary & immune conditions)
Petkov V, et al. Journal of Clinical Investigation (2003)
Human data showing altered VIP signaling in pulmonary hypertension, highlighting translational relevance of VIP pathways.
https://www.jci.org/articles/view/16522
https://pubmed.ncbi.nlm.nih.gov/12511592/
Storage Instructions
All research peptides offered are manufactured using a lyophilization (freeze-drying) process,
which is designed to enhance stability during storage and transport. When stored appropriately,
lyophilized materials are generally stable at room temperature for extended periods prior to reconstitution.
Lyophilized (Unreconstituted) Material
- Store vials away from heat, moisture, and direct light.
- For short-term storage, refrigeration at approximately 4°C (39°F) is suitable.
- For long-term storage (months to years), vials may be stored in a freezer at approximately −80°C (−112°F).
- Freezing is the preferred method for preserving stability over extended storage durations.
Reconstituted Material
- Once reconstituted using appropriate laboratory-grade solvents, materials should be stored refrigerated.
- Under refrigerated conditions, reconstituted material is commonly considered stable for up to 30 days,
depending on solvent choice, concentration, handling, and experimental conditions. - Avoid repeated freeze–thaw cycles, as these may impact material integrity.
About Lyophilization
Lyophilization is a dehydration process in which compounds are frozen and exposed to reduced pressure,
allowing ice to sublimate directly from solid to vapor. This process results in a dry, crystalline structure
that enhances stability prior to reconstitution.
⚠️ Important Notice: These materials are intended for research and laboratory use only.
Not for human or veterinary use, consumption, or application.
Recent Certificate of Analysis (COA)
99%+ Purity
Third-Party Lab Tested
Satisfaction Guaranteed
Related products
Frequently Asked Questions
Essential information about our research-grade peptides and quality standards.
What are research peptides?
Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.
Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.
What does peptide purity mean and why does it matter?
Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).
Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.
How do you ensure peptide quality?
We maintain rigorous quality control through a multi-step verification process:
- HPLC Analysis: Every batch tested to verify ≥99% purity
- Mass Spectrometry: Molecular weight confirmation for peptide identity
- Third-Party Testing: Independent laboratory verification
- Sterility Protocols: Aseptic handling and packaging procedures
- Batch Documentation: Complete traceability from synthesis to delivery
What does "Research Use Only" mean?
“Research Use Only” (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.
How are peptides shipped?
All orders are shipped with research-grade handling protocols:
- Packaging: Insulated containers with cold packs when required
- Carriers: USPS Priority Mail
- Processing: Orders placed before 12 PM EST ship same business day
- Tracking: Full tracking information provided via email
What is your return and refund policy?
We stand behind every product:
- Quality guarantee: Full replacement or refund if products don’t meet stated specifications
- Shipping issues: Free replacement for damaged or lost shipments
- Unopened returns: Accepted within 30 days for store credit
