A single-component research material supplied for controlled research environments. Lysine–Proline–Valine (KPV) is a synthetic tripeptide commonly used in research investigating inflammation pathways, immune signaling, and tissue response models.
• Lysine–Proline–Valine (KPV)
• Appearance: Lyophilized powder in a sealed research vial
$120.00
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These compounds are intended for in-vitro research use only and are not approved for human or veterinary use, consumption, or therapeutic application.
Research Focus
Research Focus
- In-vitro studies examining KPV’s role in modulating inflammatory pathways
- Investigation of its potential effects on immune cell signaling
- Development of analytical methods for tripeptide characterization (HPLC/LC-MS)
- Stability and solubility profiling of KPV under controlled laboratory storage conditions
Supportive Studies
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH) that has been studied primarily for its anti-inflammatory and immunomodulatory effects, particularly at epithelial and mucosal barriers. Unlike full α-MSH, KPV is non-pigmentary and acts locally through inhibition of NF-κB signaling, reduced pro-inflammatory cytokine release, and modulation of immune cell activation. The strongest evidence supports KPV’s role in intestinal inflammation (IBD models), epithelial barrier integrity, and immune tone regulation, with additional relevance to skin inflammation and mucosal healing. Human clinical trials are limited, but the mechanistic and animal data are consistent and well-characterized.
Key Evidence & Links
-
Foundational study – intestinal anti-inflammatory effects (IBD models)
Kannengiesser K, et al. / Brzoska T, et al. Gastroenterology (2007)
Demonstrated that KPV is actively transported by PepT1 and significantly reduces intestinal inflammation in DSS and TNBS colitis models.
https://www.gastrojournal.org/article/S0016-5085(07)01852-5/fulltext
https://pubmed.ncbi.nlm.nih.gov/18045589/ -
Mechanism – NF-κB inhibition & cytokine reduction
Brzoska T, et al. Journal of Investigative Dermatology (2004)
Showed that KPV inhibits NF-κB activation and suppresses TNF-α–induced inflammatory signaling in epithelial cells.
https://pubmed.ncbi.nlm.nih.gov/15319147/ -
α-MSH–derived peptides as anti-inflammatory regulators (review)
Brzoska T, et al. Trends in Immunology (2008)
Reviews KPV and related peptides as local anti-inflammatory mediators acting independently of melanocortin pigmentation pathways.
https://pubmed.ncbi.nlm.nih.gov/18329127/ -
Barrier integrity & epithelial protection
Kannengiesser K, et al. American Journal of Physiology – Gastrointestinal and Liver Physiology (2008)
Demonstrated that KPV improves epithelial barrier function and reduces mucosal immune activation in inflammatory models.
https://pubmed.ncbi.nlm.nih.gov/18321991/ -
Skin & mucosal inflammation context (α-MSH peptide biology)
Böhm M, et al. Endocrine Reviews (2012)
Provides broader context for α-MSH–derived peptides, including KPV, in skin immunity, inflammation control, and epithelial homeostasis.
https://academic.oup.com/edrv/article/33/5/736/2355115
https://pubmed.ncbi.nlm.nih.gov/22730531/
Storage Instructions
All research peptides offered are manufactured using a lyophilization (freeze-drying) process,
which is designed to enhance stability during storage and transport. When stored appropriately,
lyophilized materials are generally stable at room temperature for extended periods prior to reconstitution.
Lyophilized (Unreconstituted) Material
- Store vials away from heat, moisture, and direct light.
- For short-term storage, refrigeration at approximately 4°C (39°F) is suitable.
- For long-term storage (months to years), vials may be stored in a freezer at approximately −80°C (−112°F).
- Freezing is the preferred method for preserving stability over extended storage durations.
Reconstituted Material
- Once reconstituted using appropriate laboratory-grade solvents, materials should be stored refrigerated.
- Under refrigerated conditions, reconstituted material is commonly considered stable for up to 30 days,
depending on solvent choice, concentration, handling, and experimental conditions. - Avoid repeated freeze–thaw cycles, as these may impact material integrity.
About Lyophilization
Lyophilization is a dehydration process in which compounds are frozen and exposed to reduced pressure,
allowing ice to sublimate directly from solid to vapor. This process results in a dry, crystalline structure
that enhances stability prior to reconstitution.
⚠️ Important Notice: These materials are intended for research and laboratory use only.
Not for human or veterinary use, consumption, or application.
Recent Certificate of Analysis (COA)
99%+ Purity
Third-Party Lab Tested
Satisfaction Guaranteed
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Frequently Asked Questions
Essential information about our research-grade peptides and quality standards.
What are research peptides?
Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.
Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.
What does peptide purity mean and why does it matter?
Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).
Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.
How do you ensure peptide quality?
We maintain rigorous quality control through a multi-step verification process:
- HPLC Analysis: Every batch tested to verify ≥99% purity
- Mass Spectrometry: Molecular weight confirmation for peptide identity
- Third-Party Testing: Independent laboratory verification
- Sterility Protocols: Aseptic handling and packaging procedures
- Batch Documentation: Complete traceability from synthesis to delivery
What does "Research Use Only" mean?
“Research Use Only” (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.
How are peptides shipped?
All orders are shipped with research-grade handling protocols:
- Packaging: Insulated containers with cold packs when required
- Carriers: USPS Priority Mail
- Processing: Orders placed before 12 PM EST ship same business day
- Tracking: Full tracking information provided via email
What is your return and refund policy?
We stand behind every product:
- Quality guarantee: Full replacement or refund if products don’t meet stated specifications
- Shipping issues: Free replacement for damaged or lost shipments
- Unopened returns: Accepted within 30 days for store credit








