A single-component research material supplied for controlled research environments. KissPeptin-10 (10 mg) is a synthetic decapeptide used in advanced research examining reproductive hormone signaling, hypothalamic-pituitary-gonadal (HPG) axis regulation, and neuroendocrine pathway characterization in model systems.
- KissPeptin
- Appearance: Lyophilized powder in a sealed research vial
- 10 mg/vial
$110.00
These compounds are intended for in-vitro research use only and are not approved for human or veterinary use, consumption, or therapeutic application.
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Research Focus
Research Focus
- Peptide identity and purity assessment via HPLC/LC-MS
- Investigation of Kisspeptin’s role in GnRH secretion and HPG axis studies
- Development of neuroendocrine assays for reproductive hormone modeling
- Stability and solubility profiling under laboratory storage conditions
Supportive Studies
Kisspeptin is a hypothalamic neuropeptide that functions as a master regulator of the reproductive axis by stimulating gonadotropin-releasing hormone (GnRH) neurons. Through this action, kisspeptin governs puberty onset, ovulation, menstrual cyclicity, testosterone production, and fertility in both women and men. Human and animal studies consistently demonstrate that kisspeptin signaling is essential for normal hypothalamic–pituitary–gonadal (HPG) axis function, and dysregulation is linked to hypogonadotropic hypogonadism, delayed puberty, PCOS-related ovulatory dysfunction, and infertility. Beyond reproduction, emerging research suggests roles in metabolic signaling, stress integration, and sexual behavior, positioning kisspeptin as a critical neuroendocrine integrator rather than a single-purpose reproductive peptide.
Key Evidence & Links
-
Foundational discovery – Kisspeptin as a gatekeeper of puberty & reproduction
Seminara SB, et al. New England Journal of Medicine (2003)
Identified mutations in the KISS1 receptor (GPR54) as a cause of hypogonadotropic hypogonadism, establishing kisspeptin as essential for GnRH release and pubertal development.
https://www.nejm.org/doi/full/10.1056/NEJMoa035322
https://pubmed.ncbi.nlm.nih.gov/14534338/ -
Kisspeptin stimulation of GnRH, LH, and FSH in humans
Dhillo WS, et al. Journal of Clinical Endocrinology & Metabolism (2005)
Demonstrated that kisspeptin administration potently stimulates LH and FSH release in healthy men, confirming direct activation of the HPG axis in humans.
https://academic.oup.com/jcem/article/90/12/6609/2836885
https://pubmed.ncbi.nlm.nih.gov/16144949/ -
Ovulation triggering & fertility applications (human studies)
Abbara A, et al. Journal of Clinical Endocrinology & Metabolism (2015)
Showed kisspeptin can safely trigger oocyte maturation and ovulation during IVF, with reduced risk of ovarian hyperstimulation syndrome (OHSS).
https://academic.oup.com/jcem/article/100/9/3322/2836361
https://pubmed.ncbi.nlm.nih.gov/26175400/ -
Kisspeptin in women’s reproductive disorders (PCOS, hypothalamic amenorrhea)
Skorupskaite K, et al. Human Reproduction Update (2014)
Comprehensive review of kisspeptin’s role in female reproductive disorders, ovulatory dysfunction, and neuroendocrine regulation.
https://academic.oup.com/humupd/article/20/4/485/607513
https://pubmed.ncbi.nlm.nih.gov/24599916/ -
Neuroendocrine integration: metabolism, stress, and reproduction
Pinilla L, et al. Endocrine Reviews (2012)
Explains how kisspeptin integrates energy availability, metabolic signals, and stress with reproductive function.
https://academic.oup.com/edrv/article/33/5/710/2355116
https://pubmed.ncbi.nlm.nih.gov/22730530/ -
Sexual behavior & brain signaling (emerging human data)
Comninos AN, et al. Journal of Clinical Investigation (2017)
Demonstrated kisspeptin activation of limbic brain regions associated with sexual and emotional processing in humans.
https://www.jci.org/articles/view/89519
https://pubmed.ncbi.nlm.nih.gov/28112676/
Storage Instructions
All research peptides offered are manufactured using a lyophilization (freeze-drying) process,
which is designed to enhance stability during storage and transport. When stored appropriately,
lyophilized materials are generally stable at room temperature for extended periods prior to reconstitution.
Lyophilized (Unreconstituted) Material
- Store vials away from heat, moisture, and direct light.
- For short-term storage, refrigeration at approximately 4°C (39°F) is suitable.
- For long-term storage (months to years), vials may be stored in a freezer at approximately −80°C (−112°F).
- Freezing is the preferred method for preserving stability over extended storage durations.
Reconstituted Material
- Once reconstituted using appropriate laboratory-grade solvents, materials should be stored refrigerated.
- Under refrigerated conditions, reconstituted material is commonly considered stable for up to 30 days,
depending on solvent choice, concentration, handling, and experimental conditions. - Avoid repeated freeze–thaw cycles, as these may impact material integrity.
About Lyophilization
Lyophilization is a dehydration process in which compounds are frozen and exposed to reduced pressure,
allowing ice to sublimate directly from solid to vapor. This process results in a dry, crystalline structure
that enhances stability prior to reconstitution.
⚠️ Important Notice: These materials are intended for research and laboratory use only.
Not for human or veterinary use, consumption, or application.
Recent Certificate of Analysis (COA)
99%+ Purity
Third-Party Lab Tested
Satisfaction Guaranteed
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Frequently Asked Questions
Essential information about our research-grade peptides and quality standards.
What are research peptides?
Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.
Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.
What does peptide purity mean and why does it matter?
Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).
Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.
How do you ensure peptide quality?
We maintain rigorous quality control through a multi-step verification process:
- HPLC Analysis: Every batch tested to verify ≥99% purity
- Mass Spectrometry: Molecular weight confirmation for peptide identity
- Third-Party Testing: Independent laboratory verification
- Sterility Protocols: Aseptic handling and packaging procedures
- Batch Documentation: Complete traceability from synthesis to delivery
What does "Research Use Only" mean?
“Research Use Only” (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.
How are peptides shipped?
All orders are shipped with research-grade handling protocols:
- Packaging: Insulated containers with cold packs when required
- Carriers: USPS Priority Mail
- Processing: Orders placed before 12 PM EST ship same business day
- Tracking: Full tracking information provided via email
What is your return and refund policy?
We stand behind every product:
- Quality guarantee: Full replacement or refund if products don’t meet stated specifications
- Shipping issues: Free replacement for damaged or lost shipments
- Unopened returns: Accepted within 30 days for store credit








