A single-component research material supplied for controlled research environments. Hexarelin Acetate (5 mg) is a synthetic growth hormone secretagogue peptide studied for its ability to bind to GHS-R1a receptors and stimulate growth hormone release in preclinical models.
• Hexarelin Acetate
• Appearance: Lyophilized powder in a sealed research vial
$100.00
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These compounds are intended for in-vitro research use only and are not approved for human or veterinary use, consumption, or therapeutic application.
Research Focus
Research Focus
- Evaluation of growth hormone release pathways in in-vitro and in-vivo models
- Studies on ghrelin receptor (GHS-R1a) binding and downstream signaling
- Development of analytical assays for peptide quantification and purity verification
- Stability and solubility characterization under laboratory storage conditions
Supportive Studies
Hexarelin acetate is a synthetic growth hormone secretagogue (GHS) belonging to the GHRP class, known for its potent stimulation of growth hormone (GH) release through activation of the ghrelin (GHS-R1a) receptor. Compared with newer agents like ipamorelin, hexarelin is less selective and more likely to stimulate ACTH, cortisol, and prolactin, but it has been extensively studied for GH release, cardiac protection, muscle and bone metabolism, and tissue repair. Human and animal studies demonstrate that hexarelin produces robust GH pulses, increases IGF-1, and exerts direct cardioprotective effects that appear partly independent of GH signaling. Overall, hexarelin is best characterized as a powerful but non-selective GH secretagogue with a deeper historical evidence base than many newer peptides, though endocrine side effects must be acknowledged in claims-safe framing.
Key Evidence & Links
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Foundational pharmacology – potent GH secretagogue
Bowers CY, et al. Endocrinology (1991)
Identified hexarelin as a strong GH-releasing peptide acting via the GHS receptor, producing marked GH release in humans and animals.
https://pubmed.ncbi.nlm.nih.gov/1915084/ -
Human GH release & endocrine effects
Ghigo E, et al. Journal of Clinical Endocrinology & Metabolism (1994)
Demonstrated robust GH and IGF-1 increases in humans, with associated ACTH and cortisol stimulation, highlighting lower selectivity compared with newer GHRPs.
https://pubmed.ncbi.nlm.nih.gov/8175960/ -
Cardioprotective effects independent of GH
Muccioli G, et al. Endocrinology (2000)
Showed hexarelin exerts direct cardioprotective actions via cardiac GHS receptors, including improved cardiac function after ischemic injury.
https://pubmed.ncbi.nlm.nih.gov/10875224/ -
Heart failure & myocardial protection models
Broglio F, et al. European Journal of Endocrinology (2002)
Demonstrated improved cardiac performance and ventricular function in experimental heart failure models following hexarelin administration.
https://pubmed.ncbi.nlm.nih.gov/12153752/ -
Bone metabolism & GH/IGF-1 signaling
Cittadini A, et al. Journal of Clinical Endocrinology & Metabolism (2001)
Reported increased bone turnover and anabolic signaling, supporting investigation of hexarelin in bone and musculoskeletal contexts.
https://pubmed.ncbi.nlm.nih.gov/11238486/ -
Review – GH secretagogues (context & comparison)
Giustina A, et al. Endocrine Reviews (2008)
Comprehensive review comparing hexarelin, GHRPs, and newer secretagogues, outlining benefits, limitations, and endocrine tradeoffs.
https://academic.oup.com/edrv/article/29/5/535/2355197
https://pubmed.ncbi.nlm.nih.gov/18687627/
Storage Instructions
All research peptides offered are manufactured using a lyophilization (freeze-drying) process,
which is designed to enhance stability during storage and transport. When stored appropriately,
lyophilized materials are generally stable at room temperature for extended periods prior to reconstitution.
Lyophilized (Unreconstituted) Material
- Store vials away from heat, moisture, and direct light.
- For short-term storage, refrigeration at approximately 4°C (39°F) is suitable.
- For long-term storage (months to years), vials may be stored in a freezer at approximately −80°C (−112°F).
- Freezing is the preferred method for preserving stability over extended storage durations.
Reconstituted Material
- Once reconstituted using appropriate laboratory-grade solvents, materials should be stored refrigerated.
- Under refrigerated conditions, reconstituted material is commonly considered stable for up to 30 days,
depending on solvent choice, concentration, handling, and experimental conditions. - Avoid repeated freeze–thaw cycles, as these may impact material integrity.
About Lyophilization
Lyophilization is a dehydration process in which compounds are frozen and exposed to reduced pressure,
allowing ice to sublimate directly from solid to vapor. This process results in a dry, crystalline structure
that enhances stability prior to reconstitution.
⚠️ Important Notice: These materials are intended for research and laboratory use only.
Not for human or veterinary use, consumption, or application.
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Frequently Asked Questions
Essential information about our research-grade peptides and quality standards.
What are research peptides?
Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.
Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.
What does peptide purity mean and why does it matter?
Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).
Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.
How do you ensure peptide quality?
We maintain rigorous quality control through a multi-step verification process:
- HPLC Analysis: Every batch tested to verify ≥99% purity
- Mass Spectrometry: Molecular weight confirmation for peptide identity
- Third-Party Testing: Independent laboratory verification
- Sterility Protocols: Aseptic handling and packaging procedures
- Batch Documentation: Complete traceability from synthesis to delivery
What does "Research Use Only" mean?
“Research Use Only” (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.
How are peptides shipped?
All orders are shipped with research-grade handling protocols:
- Packaging: Insulated containers with cold packs when required
- Carriers: USPS Priority Mail
- Processing: Orders placed before 12 PM EST ship same business day
- Tracking: Full tracking information provided via email
What is your return and refund policy?
We stand behind every product:
- Quality guarantee: Full replacement or refund if products don’t meet stated specifications
- Shipping issues: Free replacement for damaged or lost shipments
- Unopened returns: Accepted within 30 days for store credit