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GLP-3 RT

A single-component research material supplied for controlled research environments. Suitable for studies involving GLP-1 receptor–related pathway characterization and method development in model systems.

• GLP-3 RT
• Appearance: Lyophilized powder in a sealed research vial

Price range: $200.00 through $500.00

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These compounds are intended for in-vitro research use only and are not approved for human or veterinary use, consumption, or therapeutic application.

Research Focus
Research Focus
  • Peptide identity and purity assessment via HPLC/LC-MS
  • Assay development and calibration for quantitative analysis of GLP-1 receptor–related models
  • Chromatographic method optimization for impurity profiling and peak resolution
  • Stability characterization of a lyophilized peptide under laboratory storage conditions

Retatrutide is a triple incretin receptor agonist (GLP-1 / GIP / glucagon) that represents the next evolution in obesity pharmacotherapy. Phase 2 clinical data demonstrate unprecedented magnitude and speed of weight loss (up to ~24% at 48 weeks), exceeding outcomes seen with GLP-1–only or GLP-1/GIP dual agonists. The distinguishing feature of retatrutide is glucagon receptor agonism, which increases energy expenditure, thermogenesis, and fat oxidation, while GLP-1 and GIP signaling reduce appetite and improve insulin sensitivity. Together, this produces deeper metabolic remodeling, favorable cardiometabolic shifts, and signals toward preferential fat mass loss with lean mass preservation. Phase 3 programs are underway to confirm long-term safety, durability, and cardiometabolic outcomes.

Key Evidence & Links

  1. Phase 2 landmark obesity trial (efficacy & magnitude)
    Mean weight loss up to 24.2% at 48 weeks; fastest and largest loss to date
    Jastreboff AM, et al. NEJM (2023)
    https://www.nejm.org/doi/full/10.1056/NEJMoa2301972
    https://pubmed.ncbi.nlm.nih.gov/37354147/

  2. First-in-human & translational development (mechanistic foundation)
    Energy expenditure ↑ (glucagon); food intake ↓ (GLP-1/GIP); insulin sensitivity ↑
    Coskun T, et al. Science Translational Medicine (2022)
    https://www.science.org/doi/10.1126/scitranslmed.abq1093
    https://pubmed.ncbi.nlm.nih.gov/35943788/

  3. Glucagon receptor agonism & poly-agonist rationale
    Explains thermogenesis, fat oxidation, and why triple agonists outperform
    Müller TD, et al. Nature Reviews Drug Discovery (2022)
    https://www.nature.com/articles/s41573-022-00440-w
    https://pubmed.ncbi.nlm.nih.gov/35273306/

  4. Body composition & cardiometabolic effects (Phase 2 supplement)
    Reductions in waist circumference, triglycerides, atherogenic lipids; lean-mass signal
    NEJM Supplement (2023)
    https://www.nejm.org/doi/suppl/10.1056/NEJMoa2301972/suppl_file/nejmoa2301972_appendix.pdf

  5. Foundational poly-agonist biology (insulin sensitivity & lipid oxidation)
    Mechanistic basis that informed triple-agonist development
    Finan B, et al. Nature Medicine (2015)
    https://www.nature.com/articles/nm.3775
    https://pubmed.ncbi.nlm.nih.gov/25894613/

  6. Phase 3 clinical development (TRIUMPH program)
    Large-scale safety, durability, maintenance & cardiometabolic endpoints
    ClinicalTrials.gov
    https://clinicaltrials.gov/search?cond=Obesity&term=retatrutide

All research peptides offered are manufactured using a lyophilization (freeze-drying) process,
which is designed to enhance stability during storage and transport. When stored appropriately,
lyophilized materials are generally stable at room temperature for extended periods prior to reconstitution.

Lyophilized (Unreconstituted) Material

  • Store vials away from heat, moisture, and direct light.
  • For short-term storage, refrigeration at approximately 4°C (39°F) is suitable.
  • For long-term storage (months to years), vials may be stored in a freezer at approximately −80°C (−112°F).
  • Freezing is the preferred method for preserving stability over extended storage durations.

Reconstituted Material

  • Once reconstituted using appropriate laboratory-grade solvents, materials should be stored refrigerated.
  • Under refrigerated conditions, reconstituted material is commonly considered stable for up to 30 days,
    depending on solvent choice, concentration, handling, and experimental conditions.
  • Avoid repeated freeze–thaw cycles, as these may impact material integrity.

About Lyophilization

Lyophilization is a dehydration process in which compounds are frozen and exposed to reduced pressure,
allowing ice to sublimate directly from solid to vapor. This process results in a dry, crystalline structure
that enhances stability prior to reconstitution.

⚠️ Important Notice: These materials are intended for research and laboratory use only.
Not for human or veterinary use, consumption, or application.

Click here to view the most recent certificate of analysis (COA) – 10 mg

Click here to view the most recent certificate of analysis (COA) – 20 mg

Click here to view the most recent certificate of analysis (COA) – 30 mg

Click here to view the most recent certificate of analysis (COA) – 40 mg

Click here to view the most recent certificate of analysis (COA) – 50 mg

99%+ Purity

Third-Party Lab Tested

Satisfaction Guaranteed

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Frequently Asked Questions

Essential information about our research-grade peptides and quality standards.

What are research peptides?

Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.

Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.

Key characteristics: High purity (≥99%), lyophilized form for stability, accompanied by Certificates of Analysis (COA), and manufactured under strict quality control protocols.

Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).

Our Standard: All our research peptides maintain ≥99% purity, verified by third-party laboratory testing and documented in our Certificates of Analysis.

Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.

We maintain rigorous quality control through a multi-step verification process:

  • HPLC Analysis: Every batch tested to verify ≥99% purity
  • Mass Spectrometry: Molecular weight confirmation for peptide identity
  • Third-Party Testing: Independent laboratory verification
  • Sterility Protocols: Aseptic handling and packaging procedures
  • Batch Documentation: Complete traceability from synthesis to delivery

“Research Use Only” (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.

All orders are shipped with research-grade handling protocols:

  • Packaging: Insulated containers with cold packs when required
  • Carriers: USPS Priority Mail
  • Processing: Orders placed before 12 PM EST ship same business day
  • Tracking: Full tracking information provided via email

We stand behind every product:

  • Quality guarantee: Full replacement or refund if products don’t meet stated specifications
  • Shipping issues: Free replacement for damaged or lost shipments
  • Unopened returns: Accepted within 30 days for store credit
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